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time 3 days ago 5 comments 956 like

One year after the birth of the world’s first two cloned primates, a team in China has used CRISPR gene editing and cloning to create monkeys that show some symptoms of depression and schizophrenia. • While some researchers have praised the work’s potential for helping us understand psychiatric disorders in humans, others have raised ethical concerns. • Lead scientist Hung-Chun Chang of the Institute of Neuroscience in Shanghai told New Scientist about how he hopes the monkeys will help us better understand mental health and find new treatments. • What symptoms do these monkeys have? The most direct result is that they are not getting enough sleep. Healthy monkeys usually sleep for 9 hours every night, but these monkeys can’t rest for longer than 6 hours. • They are also afraid of people, which is very unusual for such a sociable animal, and they show no interest in new environments. • We also found they have persistently high cortisol levels in blood tests. Elevated cortisol has been linked to anxiety and depression in monkeys and humans in past research. • Previous studies have shown that people with schizophrenia are less able to detect and pay attention to new stimuli, including sounds. We found that these monkeys have lower levels of brain activity compared with healthy monkeys when unexpected sounds were played. • What are you hoping to learn from this work? We will use these monkeys for drug testing. We have three general goals. First, we are curious whether drugs for body clock regulation, such as sleeping pills, are helpful in alleviating depression. • Second, we want to know how effective the medicines we use currently for mental health conditions are. Ultimately, we aim to create better treatments for people. • What else is your team working on? We are trying to create an Alzheimer’s model. Because the disease is age-related and involves more-complex genetic mutations, it will probably take another two to three years until the monkeys show symptoms. [credit: Yvaine Ye, New Scientist]🌐

time 11 minutes ago 7 comments 230 like

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